Aging Skin & Wrinkles

GHK-Cu is effective both topically and subcutaneously. Topical application (serums, creams) has the most published human data for skin applications — studies show improvements in skin density, thickness, and the reduction of fine lines within 4–8 weeks. Subcutaneous injection delivers higher systemic concentrations and may achieve broader anti-inflammatory and gene-activation effects beyond the skin.

Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by the St. Petersburg Institute of Bioregulation. It has over 40 years of research by Professor Vladimir Khavinson. It activates telomerase, the enzyme that rebuilds telomere length, and has demonstrated life extension in multiple animal models. It also normalises melatonin secretion from the pineal gland and exhibits antioxidant activity.

GHK-Cu topical effects on skin texture and fine lines are typically noticeable within 4–8 weeks of consistent daily use. Subcutaneous protocols show more pronounced improvements at 8–12 weeks. Epithalon's cellular anti-aging effects operate on a longer timescale — telomere restoration benefits accumulate over months to years of periodic cycling. The recommended protocol is 10 days on, 5 months off, twice per year.