Weight Loss & Obesity

AOD-9604 is a modified fragment (amino acids 176–191) of the GH molecule, specifically the region responsible for lipolytic activity. Unlike full GH, it does not stimulate IGF-1, does not affect blood glucose, and has no anabolic effect on muscle or bone. Phase I/II trials in humans showed it was safe and well-tolerated at doses up to 400mcg/kg.

CJC-1295 is a GHRH analogue that extends the GH release window, while Ipamorelin is a selective GHS (ghrelin mimetic) that triggers clean GH pulses without spiking cortisol or prolactin. Used together, they create a synergistic pulse that closely mimics natural nocturnal GH secretion — maximising fat metabolism while preserving lean mass.

Metabolic peptides enhance the body's fat-burning mechanisms but are not a substitute for a caloric deficit. Animal studies and Phase II trials show AOD-9604 reduces body weight even without dietary intervention, but the effect is amplified with a moderate energy deficit and resistance training. Lean mass preservation is most pronounced when combined with adequate protein intake.